South Carolina is the 23rd largest state in population in the United States. The 2021 population is 5,179,334. Below is a table of the most populated cities and counties in South Carolina.
| Most Populated SC Cities |
|---|
| Charleston - 150,227 |
| Columbia - 136,632 |
| North Charleston - 114,852 |
| Mount Pleasant - 90,801 |
| Rock Hill - 74,372 |
| Greenville - 70,720 |
| Summerville - 50,915 |
| Goose Creek - 45,946 |
| Sumter - 43,463 |
| Florence - 39,899 |
| Most Populated SC Counties |
|---|
| Greenville - 525,534 |
| Richland - 416,147 |
| Charleston - 408,235 |
| Horry - 351,029 |
| Spartanburg - 327,997 |
| Lexington - 293,991 |
| York - 282,090 |
| Berkeley - 229,861 |
| Anderson - 203,718 |
| Beaufort - 187,117 |
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