(fl. 1521) Francisco de Chicora was an Indian slave from South Carolina who was brought back to Spain in 1521.

(ca. 1500-1542) Hernando de Soto was a Spanish explorer and conquistador who explored in South Carolina.

(1520-1565) Jean Ribault was a French navigator who led an expedition to the New World in 1562 that founded the outpost of Charlesfort on Paris Island.