(1946- ) Born in Columbia, SC, Charles F. Bolden, Jr. is the current head of the NASA federal agency. He is a retired US Marine major general and former NASA astronaut.
(1935- ) Colonel Charles Moss Duke, Jr. is a retired USAF Brigadier General and former NASA astronaut and engineer. He was born in Charlotte, NC and attended Lancaster High School in Lancaster, SC.
(1809-1866) Robert Wilson Gibbes was a physician and naturalist who wrote paleontology articles on marine fossils found in South Carolina.
(1883-1941) Ernest Everett Just was a renowned African American scientist from Charleston, SC.
(1950-1986) Born in Lake City, SC, Ronald McNair is an astronaut killed in the explosion of the Space Shuttle Challenger.
(1944- ) Kary Mullis grew up in Columbia, SC and is an esteemed biochemist and Nobel laureate.
(1723–1793) Eliza Lucas Pinckney was a daughter of a plantation owner who is best known for her experiments with creating blue die from indigo plants, which led to indigo becoming one of the colony’s most important cash crops.