John McQueen the U.S. Representative for South Carolina from 1853 to 1860. He also was a member of the Confederate States Congress during the American Civil War.
Ellison DuRant Smith was a Democratic politician in South Carolina who was widely known for his racist and segregationist views and advocacy of white supremacy.
James Marion Sims is credited as the "father of modern gynecology" for developing tools and surgical techniques related to women's reproductive health.