Alexander Samuel Salley was a historian whose work and dedication to preserving South Carolina's history led to the creation of the South Carolina Department of Archives and History.
Eulalie Chafee Salley from Aiken, SC fought for the right for women to vote.
Dori Sanders is a peach farmer and author from York County, who wrote the best-selling book Clover.
Mark Sanford is the 115th of South Carolina.
Celia Dial Saxon was a teacher and one of the founders of the Fairwold Industrial Home for Negro Girls and the Wilkinson Orphanage of Negro Children.
Beaufort native Valerie Sayers is the author of six novels.
William Harrison Scarborough was a portraitist and miniaturist.
Robert Kingston Scott was the 74th Governor of South Carolina
Tim Scott is a member of the U.S. Senate from South Carolina.
Edwin Seibels was a businessman from Edgefield, SC, who invented a vertical filing system that revolutionized record-keeping.
James C. Self owned several textile mills in Greenwood, SC.
Civil rights activist, educator
Mike Sharperson was an MLB infielder who played for the Toronto Blue Jays, Los Angeles Dodgers, and Atlanta Braves.
Physician, public health official
Modjeska Monteith Simkins was an African American civil rights activist who was the Secretary of the NAACP in South Carolina and helped write the court case for Briggs v. Elliott.
Philip Simmons was a nationally acclaimed Charleston blacksmith.
William Gilmore Simms was a poet, novelist, and historian who wrote History of South Carolina (1842), which became a standard school textbook on the state’s history.
Poet, novelist, playwright, historian. Her primary love was poetry, with a focus on lyrical verse, sonnets, and nature poems.
William Dunlap Simpson was the 78th Governor of South Carolina.
James Marion Sims is credited as the "father of modern gynecology" for developing tools and surgical techniques related to women's reproductive health.
Jerome Singleton, Jr. is a Paralympic gold medalist from South Carolina.
George Singleton is an author and recipient of the Guggenheim fellowship, the Corrington Award for Literary Excellence, the Hillsdale Award for Fiction, and a Pushcart Prize.
Known as "The Blues Doctor," Drink Small is a soul blues and electric blues guitarist, pianist, singer, and songwriter.
Robert Smalls was a Beaufort slave who hijacked a Confederate steamship, disguised himself as a white captain, and sailed to the Union-controlled enclave in Beaufort–Port Royal–Hilton Head area safety.
Vertamae Smart-Grosvenor was a culinary anthropologist, griot, food writer, and broadcaster on public media.
Alice Ravenel Huger Smith was an artist during the Charleston Renaissance known for her watercolors and woodblock prints.
Josiah Smith was a clergyman who championed the causes of the Great Awakening and later the American independence.
Ellison DuRant Smith was a Democratic politician in South Carolina who was widely known for his racist and segregationist views and advocacy of white supremacy.
Louise Smith was known as “the first lady of racing.” Louise Smith was the first professional woman race car driver.
Gregory White Smith was a biographer of Jackson Pollock and Vincent van Gogh.
Clara Smith was a blues singer from Spartanburg, South Carolina. She was nicknamed the "Queen of the Moaners."
Monroe K. Spears was the editor of the Sewanee Review and the Libbie Shearn Moody Professor of English at Rice University.
Mickey Spillane was a well-known author of many crime novels and his signature detective character, Mike Hammer.
Elliott White Springs was a South Carolina businessman and an American flying ace of World War I.
Dawn Staley is a three-time Olympic Gold medalist and head coach for the South Carolina Gamecocks Women's Basketball team.
Blues and Gospel singer
Mark Steadman is a writer. He taught humor and the American novel at Clemson University.
Max Steele was an author and educator from Greenville, SC.
ND Stevenson is the creator of She-Ra and the Princess of Power and Nimona.
Educator
Angie Stone is a singer, songwriter, actress, and record producer. She rose to frame in the late 1970s as a member of the hip hop trio, The Sequence.
Freddie Stowers was a member of the 371st Infantry Regiment in World War I who was posthumously awarded a Congressional Medal of Honor.
Lily Strickland was a composer, painter, and writer from Anderson, South Carolina.
Jacob Stroyer was a former slave who became a preacher in Massachusetts. He is best known for his autobiography, My Life in the South.
Thomas Sumter was a distinguished general in the Revolutionary War who lived in Sumter County.
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